Heart Rate and Cardiovascular Disease: An Alternative to Beta Blockers
نویسندگان
چکیده
Ivabradine, an I(f) inhibitor, acts primarily on the sinoatrial node and is used to reduce the heart rate with minimal effect on myocardial contractility, blood pressure, and intracardiac conduction. Heart rate reduction is an important aspect of care in patients with chronic stable angina and heart failure. Many patients with coronary artery disease have coexisting asthma or chronic obstructive airway disease, and most of them are unable to tolerate beta blockers. Ivabradine may thus be a useful medicine in therapeutic heart rate management especially in patients who are intolerant of beta-blockers.
منابع مشابه
اسید آسکوربیک خوراکی به همراه بتا بلوکرها روشی موثر برای کاهش فیبریلاسیون دهلیزی به دنبال عمل جراحی بای پس عروق کرونر
Background: Adrenergic beta antagonists are not sufficient to prevent atrial fibrillation after coronary artery bypass graft (CABG). This study was designed to evaluate the effect of ascorbic acid as an adjunct to beta-blockers in prevention of post-CABG atrial fibrillation Methods: Patients who were more than 50 years old and scheduled to undergo CABG were included if they were treated with b...
متن کاملRelation of beta-blocker-induced heart rate lowering and cardioprotection in hypertension.
OBJECTIVES The purpose of this study was to evaluate the role of heart rate reduction with beta-blockers on the risk of cardiovascular events in patients with hypertension. BACKGROUND Resting heart rate has been shown to be a risk factor for cardiovascular morbidity and mortality in the general population and in patients with heart disease such as hypertension, myocardial infarction, and hear...
متن کاملPrognosis in heart failure: the value of parameter-changes over time.
and, more recently, that reducing the heart rate of monkeys with beta-blockers or sino-atrial node ablation retards coronary atherosclerosis. In humans, mortality reduction has been shown to occur, in persons with existing coronary disease, if the heart rate is reduced with beta-blockers by more than 14 beats . min . Proof of the efficacy of reducing the heart rate to avoid atherosclerotic card...
متن کاملHeart rate control with adrenergic blockade: Clinical outcomes in cardiovascular medicine
The sympathetic nervous system is involved in regulating various cardiovascular parameters including heart rate (HR) and HR variability. Aberrant sympathetic nervous system expression may result in elevated HR or decreased HR variability, and both are independent risk factors for development of cardiovascular disease, including heart failure, myocardial infarction, and hypertension. Epidemiolog...
متن کاملErectile Function in Cardiovascular Disease and Hypertension: the Role of Nebivolol
Beta blockers are used for the management of arterial hypertension and are gold standard treatment for coronary artery disease and heart failure, medical conditions that affect large numbers of older patients and are associated with very high morbidity and mortality rates. Lifelong therapy in primary and secondary prevention (without and with established cardiovascular disease, respectively) is...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2009 شماره
صفحات -
تاریخ انتشار 2009